The Quakes will open their 2022 schedule at home against the New York Red Bulls with kickoff at 3pm PT. This will be the first meeting since March 16, 2019 and the first in San Jose since October 6, 2018.
The remaining matches will be announced before the end of the year, with the final game to be played on Sunday October 9 with MLS Cup to be played on Saturday November 5–two weeks before the World Cup begins on November 19 on the island nation of Qatar in the Middle East. As of now, this is the only game on the Quakes schedule that has been confirmed for 2022.